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RA190
Catalog No. T13858Cas No. 1617495-03-0
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $117 | In Stock | |
| 10 mg | $171 | In Stock | |
| 25 mg | $258 | In Stock | |
| 50 mg | $460 | In Stock | |
| 100 mg | $676 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $153 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. |
| Targets&IC50 | HeLa cells:0.15 μM |
| In vitro | Multiple myeloma (MM) lines, even those resistant to bortezomib, are sensitive to RA190 via endoplasmic reticulum stress-related apoptosis. RA190 stabilizes targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially kills HPV-transformed cells. |
| In vivo | RA190 administration profoundly reduces growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retards HPV16+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses. |
| Molecular Weight | 596.76 |
| Formula | C28H23Cl5N2O2 |
| Cas No. | 1617495-03-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 95 mg/mL (159.19 Mm) |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。 Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
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