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RA190
🥰Excellent
Catalog No. T13858Cas No. 1617495-03-0
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
RA190
🥰Excellent
Purity: 97.70%
Catalog No. T13858Cas No. 1617495-03-0
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $117 | In Stock | |
| 10 mg | $171 | In Stock | |
| 25 mg | $258 | In Stock | |
| 50 mg | $460 | In Stock | |
| 100 mg | $676 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $153 | In Stock |
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Purity:97.70%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. |
| Targets&IC50 | HeLa cells:0.15 μM |
| In vitro | Multiple myeloma (MM) lines, even those resistant to bortezomib, are sensitive to RA190 via endoplasmic reticulum stress-related apoptosis. RA190 stabilizes targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially kills HPV-transformed cells. |
| In vivo | RA190 administration profoundly reduces growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retards HPV16+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses. |
| Molecular Weight | 596.76 |
| Formula | C28H23Cl5N2O2 |
| Cas No. | 1617495-03-0 |
| Smiles | Cl.N[C@@H](Cc1ccccc1)C(=O)N1C\C(=C\c2ccc(Cl)c(Cl)c2)C(=O)\C(C1)=C/c1ccc(Cl)c(Cl)c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 95 mg/mL (159.19 Mm) |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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