Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 148.00 | |
10 mg | In stock | $ 247.00 | |
25 mg | In stock | $ 418.00 | |
50 mg | In stock | $ 596.00 | |
100 mg | In stock | $ 863.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead. |
In vivo | RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1]. |
Synonyms | RA375 |
Molecular Weight | 588.99 |
Formula | C30H25ClN4O7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (212.22 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RA375 Proteases/Proteasome Ubiquitination Proteasome RA-375 RA 375 inhibitor inhibit