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Raloxifene

🥰Excellent
Catalog No. T20419Cas No. 84449-90-1
Alias Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, Keoxifene

Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.

Raloxifene

Raloxifene

🥰Excellent
Purity: 99.39%
Catalog No. T20419Alias Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, KeoxifeneCas No. 84449-90-1
Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.
Pack SizePriceAvailabilityQuantity
2 mg$49In Stock
5 mg$71In Stock
10 mg$118In Stock
25 mg$220In Stock
1 mL x 10 mM (in DMSO)$81In Stock
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Purity:99.39%
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Product Introduction

Bioactivity
Description
Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.
In vitro
Raloxifene (10 μM and 50 μM) treated cells showed an increase in the percentage of cells with fragmented nuclei of 31 to 41 percent and 45 to 66 percent, respectively, after 12 and 24 hours of exposure.
Treatment with Raloxifene (50 μM) resulted in increased autophagy activity in host cells, helping to prevent intracellular bacterial invasion and proliferation. [1]
Treatment with Raloxifene((40-100 μM) prevented the dissolution of stress particles (SG) and promoted cell death during hypoxia of U251 and U3024 primary glioblastoma (GBM) cells. [4]
In vivo
Raloxifene (10 mg/kg) induced significant reductions of urea and creatinine, TNF-α, IL-1β and caspase-3 in renal isis-reperfusion injury mouse models, suggesting renal protection. [2]
Treatment with Raloxifene (10 mg/kg) alleviates vision defects caused by initial cell injury (OBI) and may be associated with a reduction in the proinflammatory effects of microglia. [3]
AliasRaloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, Keoxifene
Chemical Properties
Molecular Weight473.58
FormulaC28H27NO4S
Cas No.84449-90-1
SmilesO=C(C1=CC=C(OCCN2CCCCC2)C=C1)C3=C(SC4=CC(O)=CC=C43)C=5C=CC(O)=CC5
Relative Density.1.289 g/cm3
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (168.93 mM), Sonication is recommended.
Ethanol: 9 mg/mL (19.00 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.1116 mL10.5579 mL21.1158 mL105.5788 mL
5 mM0.4223 mL2.1116 mL4.2232 mL21.1158 mL
10 mM0.2112 mL1.0558 mL2.1116 mL10.5579 mL
DMSO
1mg5mg10mg50mg
20 mM0.1056 mL0.5279 mL1.0558 mL5.2789 mL
50 mM0.0422 mL0.2112 mL0.4223 mL2.1116 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0558 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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