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Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $49 | In Stock | |
5 mg | $71 | In Stock | |
10 mg | $118 | In Stock | |
25 mg | $220 | In Stock | |
1 mL x 10 mM (in DMSO) | $81 | In Stock |
Description | Raloxifene (LY139481) is a selective estrogen receptor modulator that exhibits both estrogen agonist and antagonist activities at certain sites, with antiviral activity against viruses like Ebola, influenza, and HCV, useful for studying viral infections. |
In vitro | Raloxifene (10 μM and 50 μM) treated cells showed an increase in the percentage of cells with fragmented nuclei of 31 to 41 percent and 45 to 66 percent, respectively, after 12 and 24 hours of exposure. Treatment with Raloxifene (50 μM) resulted in increased autophagy activity in host cells, helping to prevent intracellular bacterial invasion and proliferation. [1] Treatment with Raloxifene((40-100 μM) prevented the dissolution of stress particles (SG) and promoted cell death during hypoxia of U251 and U3024 primary glioblastoma (GBM) cells. [4] |
In vivo | Raloxifene (10 mg/kg) induced significant reductions of urea and creatinine, TNF-α, IL-1β and caspase-3 in renal isis-reperfusion injury mouse models, suggesting renal protection. [2] Treatment with Raloxifene (10 mg/kg) alleviates vision defects caused by initial cell injury (OBI) and may be associated with a reduction in the proinflammatory effects of microglia. [3] |
Alias | Raloxifenum, Pharoxifene, LY156758 free base, LY139481, LY1 39481, Keoxifene |
Molecular Weight | 473.58 |
Formula | C28H27NO4S |
Cas No. | 84449-90-1 |
Smiles | O=C(C1=CC=C(OCCN2CCCCC2)C=C1)C3=C(SC4=CC(O)=CC=C43)C=5C=CC(O)=CC5 |
Relative Density. | 1.289 g/cm3 |
Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (168.93 mM), Sonication is recommended. Ethanol: 9 mg/mL (19.00 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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