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RBN012759
Catalog No. T22414Cas No. 2360851-29-0
RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2]
RBN012759
Catalog No. T22414Cas No. 2360851-29-0
RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $107 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $455 | In Stock | |
| 25 mg | $679 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,380 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $365 | In Stock |
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Purity:99.96%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2] |
| Targets&IC50 | PARP14:<3 nM (IC50), PARP16:6 μM (IC50), PARP12:5 μM (IC50), PARP5b:10 μM (IC50), PARP11:1 μM (IC50), PARP6:4 μM (IC50), PARP4:10 μM (IC50), PARP8:20 μM (IC50), PARP10:1 μM (IC50), PARP7:4 μM (IC50), PARP15:3 μM (IC50), PARP5a:8 μM (IC50) |
| In vitro | METHODS: B cells were treated with RBN012759 (1 or 0.33 μM ) and added once daily. Cultures were harvested and counted on day 5 and the supernatant was collected for ELISA. RESULTS RBN012759 induced a decrease in IgE. [1] METHODS: RBN0127599 (0.001-10 μM) was tested in IFN-γ stimulated human primary macrophages and RAW264.7 cells to observe the effect of RBN0127599 on the expression of PARP14 protein in vitro. RESULTS The EC50 value (half-maximal effect concentration) observed in RAW264.7 cells was 10 μM, and in human macrophages it was 8 μM, indicating that RBN0127599 showed effective inhibition of the target PARP14 within these concentration ranges. [2] |
| In vivo | METHODS: RBN012759 (500 mg/kg,i.g) twice daily. Investigators collected plasma samples 2 hours after the last dose (i.e., after the penultimate dose) and on the last day to determine plasma levels of RBN012759 using liquid chromatography-mass spectrometry. RESULTS RBN012759 was effective in reducing allergen-induced IgE (immunoglobulin E) overproduction and mucus overproduction. treatment with RBN012759 resulted in a decrease in overall mucus scores in lung tissue, while the number of inflammatory cells recovered from bronchoalveolar lavage fluid (BALF) and the proportion of eosinophils recovered were significantly reduced in the bronchial-alveolar lavage fluid (BALF) of RBN012759-treated mice. were significantly reduced. [1] METHODS: RBN012759 was tested in a C57BL/6 mouse model by oral administration (BID) at doses of 300 mg/kg and 500 mg/kg for 7 days. RESULTS The 500 mg/kg group showed an increase in PARP14 protein levels, while the 300 mg/kg group did not, indicating that RBN012759 can effectively and specifically target PARP14 in vivo at higher doses. [2] |
| Molecular Weight | 378.46 |
| Formula | C19H23FN2O3S |
| Cas No. | 2360851-29-0 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (31.71 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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