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RK-9123016
🥰Excellent
Catalog No. T28543Cas No. 955900-27-3
Alias RK9123016, RK 9123016
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
RK-9123016
🥰Excellent
Purity: 100%
Catalog No. T28543Alias RK9123016, RK 9123016Cas No. 955900-27-3
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | 47 € | In Stock | |
| 10 mg | 71 € | In Stock | |
| 25 mg | 121 € | In Stock | |
| 50 mg | 182 € | In Stock | |
| 100 mg | 272 € | In Stock | |
| 200 mg | 409 € | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression. |
| In vitro | RK-9123016 inhibited the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM in vitro electrophoretic mobility shift assay. RK-9123016 inhibited the SIRT2 activity in MCF-7 cells by concentration dependent manner (0-30 µM). |
| Alias | RK9123016, RK 9123016 |
| Molecular Weight | 374.42 |
| Formula | C16H18N6O3S |
| Cas No. | 955900-27-3 |
| Smiles | C(C1=C(OC)C=CC(C=NNC(NCC=C)=S)=C1)N2C=C(N(=O)=O)C=N2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.75 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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