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Ro 25-6981 Maleate
🥰Excellent
Catalog No. T12758LCas No. 1312991-76-6
Alias Ro-25-6981 Maleate, Ro 256981 Maleate
Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 μM for NR1C/NR2B and 52 μM for NR1C/NR2A receptor subunit combinations).
Ro 25-6981 Maleate
🥰Excellent
Purity: 99.42%
Catalog No. T12758LAlias Ro-25-6981 Maleate, Ro 256981 MaleateCas No. 1312991-76-6
Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 μM for NR1C/NR2B and 52 μM for NR1C/NR2A receptor subunit combinations).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $117 | In Stock | |
| 10 mg | $159 | In Stock | |
| 25 mg | $339 | In Stock | |
| 50 mg | $567 | In Stock | |
| 100 mg | $827 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $86 | In Stock |
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Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ro 25-6981 Maleate is a potent and selective activity-dependent NMDA receptor blocker, specifically targeting the NR2B subunit (IC50 values are 0.009 μM for NR1C/NR2B and 52 μM for NR1C/NR2A receptor subunit combinations). |
| In vivo | In 6-OHDA-lesioned rats, Ro 25-6981 Maleate (0.39-12.5 mg/kg; intraperitoneal injection) dose-dependently induces contralateral tight nose-to-tail rotations and elicits a weak ipsilateral circling response, indicating a mild nonspecific stimulatory action of the compound[1]. |
| Alias | Ro-25-6981 Maleate, Ro 256981 Maleate |
| Molecular Weight | 455.54 |
| Formula | C26H33NO6 |
| Cas No. | 1312991-76-6 |
| Smiles | OC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 4 mg/mL (8.78 mM), Sonication is recommended. DMSO: 61 mg/mL (133.91 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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