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Ro 25-6981 Maleate

Catalog No. T12758LCas No. 1312991-76-6

Ro 25-6981 Maleate is a selective NR2B subunit-specific NMDA receptor antagonist with anticonvulsant and antidepressant activity, which can be used in the study of neurological disorders such as Parkinson's and epilepsy.

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Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$72	In Stock
10 mg	$98	In Stock
25 mg	$168	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock

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Product Introduction

Bioactivity

Description	Ro 25-6981 Maleate is a selective NR2B subunit-specific NMDA receptor antagonist with anticonvulsant and antidepressant activity, which can be used in the study of neurological disorders such as Parkinson's and epilepsy.
In vivo	In 6-OHDA-lesioned rats, Ro 25-6981 Maleate (0.39-12.5 mg/kg; intraperitoneal injection) dose-dependently induces contralateral tight nose-to-tail rotations and elicits a weak ipsilateral circling response, indicating a mild nonspecific stimulatory action of the compound[1].
Alias	Ro-25-6981 Maleate, Ro 256981 Maleate

Chemical Properties

Molecular Weight	455.54
Formula	C26H33NO6
Cas No.	1312991-76-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 4 mg/mL (8.78 mM)

DMSO: 61 mg/mL (133.91 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1952 mL	10.9760 mL	21.9520 mL	109.7598 mL
5 mM	0.4390 mL	2.1952 mL	4.3904 mL	21.9520 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2195 mL	1.0976 mL	2.1952 mL	10.9760 mL
20 mM	0.1098 mL	0.5488 mL	1.0976 mL	5.4880 mL
50 mM	0.0439 mL	0.2195 mL	0.4390 mL	2.1952 mL
100 mM	0.0220 mL	0.1098 mL	0.2195 mL	1.0976 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc