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RU 58841

🥰Excellent
Catalog No. T2236Cas No. 154992-24-2
Alias RU58841, PSK-3841, HMR-3841

RU 58841 (PSK-3841) is a specific androgen receptor antagonist with significant effects on hair regrowth.

RU 58841

RU 58841

🥰Excellent
Purity: 99.77%
Catalog No. T2236Alias RU58841, PSK-3841, HMR-3841Cas No. 154992-24-2
RU 58841 (PSK-3841) is a specific androgen receptor antagonist with significant effects on hair regrowth.
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$63In Stock
25 mg$108In Stock
50 mg$143In Stock
100 mg$207In Stock
500 mg$515In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Purity:99.77%
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Product Introduction

Bioactivity
Description
RU 58841 (PSK-3841) is a specific androgen receptor antagonist with significant effects on hair regrowth.
Kinase Assay
In vitro Protein Kinase, PI3K, and mTOR Assays: PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
AliasRU58841, PSK-3841, HMR-3841
Chemical Properties
Molecular Weight369.34
FormulaC17H18F3N3O3
Cas No.154992-24-2
SmilesCC1(C)N(CCCCO)C(=O)N(C1=O)c1ccc(C#N)c(c1)C(F)(F)F
Relative Density.1.39
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (108.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7075 mL13.5377 mL27.0753 mL135.3766 mL
5 mM0.5415 mL2.7075 mL5.4151 mL27.0753 mL
10 mM0.2708 mL1.3538 mL2.7075 mL13.5377 mL
20 mM0.1354 mL0.6769 mL1.3538 mL6.7688 mL
50 mM0.0542 mL0.2708 mL0.5415 mL2.7075 mL
100 mM0.0271 mL0.1354 mL0.2708 mL1.3538 mL

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