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SCFSkp2-IN-2

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Purity:99.28%

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COA HPLC HNMR

SCFSkp2-IN-2

Catalog No. T72043Cas No. 1375060-02-8

SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$64	In Stock
25 mg	$128	In Stock
50 mg	$213	In Stock
100 mg	$372	In Stock
500 mg	$869	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.
In vitro	SCFSkp2-IN-2 (Compound AAA-237) (0.3-3 μM ; 24-72 h) binds directly to Skp2, leading to degradation of Skp2 by the proteasome.AAA-237 has no significant effect on Skp2 mRNA expression, but has a time-dependent inhibitory effect on Skp2 protein expression in NSCLC cells.[1] SCFSkp2-IN-2 (0.3-3 μM ; 24-72 h) inhibited the proliferation of A549 and H1299 cells in a dose- and time-dependent manner.[1] SCFSkp2-IN-2 (0.3-3 μM ; 24-72 h) blocks the cell cycle at the G0/G1 checkpoint by regulating the Skp2-Cip/Kip and PI3K/Akt-FOXO1 signaling pathways.[1] SCFSkp2-IN-2 (0.3-3 μM ; 24-72 h) induces apoptosis in A549 and H1299 cells in a dose- and time-dependent manner.[1] SCFSkp2-IN-2 (0.3 μM ; 1-7 days) induces NSCLC cell senescence.[1]
In vivo	SCFSkp2-IN-2 (Compound AAA-237) (15 or 45 mg/kg ; i.p. ; daily for 14 days) showed antitumor activity in a mouse model of lung cancer A549 xenograft.[1]

Chemical Properties

Molecular Weight	312.37
Formula	C17H20N4O2
Cas No.	1375060-02-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (360.2 mM )

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2013 mL	16.0067 mL	32.0133 mL	160.0666 mL
5 mM	0.6403 mL	3.2013 mL	6.4027 mL	32.0133 mL
10 mM	0.3201 mL	1.6007 mL	3.2013 mL	16.0067 mL
20 mM	0.1601 mL	0.8003 mL	1.6007 mL	8.0033 mL
50 mM	0.0640 mL	0.3201 mL	0.6403 mL	3.2013 mL
100 mM	0.0320 mL	0.1601 mL	0.3201 mL	1.6007 mL

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