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Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $430 | In Stock | |
10 mg | $636 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,360 | In Stock | |
100 mg | $1,830 | In Stock | |
500 mg | $3,680 | In Stock | |
1 mL x 10 mM (in DMSO) | $517 | In Stock |
Description | Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor. |
Targets&IC50 | p38:< 0.005 µM, p38:1.5 µM |
In vivo | Oral treatment with the SCIO-323 included delivery for 3 weeks and stopping for 3 weeks, delivery for 3 weeks after an initial 3-week delay, and delivery for 6 weeks continuously. Administration of the SCIO-323 continuously for 6 weeks with/without the presence of particles, or for the initial 3 of 6 weeks had minor effects on bone ingrowth. After establishing a particle-induced chronic inflammatory reaction for 3 weeks, administration of SCIO-323 for a subsequent 3 weeks suppressed net bone formation. The activity of osteoclast-like cells remained low among all treatments when compared with the first control.[1] |
Molecular Weight | 479.54 |
Formula | C27H30FN3O4 |
Cas No. | 309913-51-7 |
Smiles | C(C(N(C)C)=O)(=O)C=1C=2C(=CC(OC)=C(C(=O)N3CCC(CC4=CC=C(F)C=C4)CC3)C2)N(C)C1 |
Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (57.35 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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