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Scio-323

🥰Excellent
Catalog No. T68139Cas No. 309913-51-7

Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.

Scio-323

Scio-323

🥰Excellent
Purity: 100.00%
Catalog No. T68139Cas No. 309913-51-7
Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$430In Stock
10 mg$636In Stock
25 mg$987In Stock
50 mg$1,360In Stock
100 mg$1,830In Stock
500 mg$3,680In Stock
1 mL x 10 mM (in DMSO)$517In Stock
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Purity:100.00%
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Product Introduction

Bioactivity
Description
Scio-323 is an orally available p38 mitogen-activated protein (MAPK) kinase inhibitor.
Targets&IC50
p38:< 0.005 µM, p38:1.5 µM
In vivo
Oral treatment with the SCIO-323 included delivery for 3 weeks and stopping for 3 weeks, delivery for 3 weeks after an initial 3-week delay, and delivery for 6 weeks continuously. Administration of the SCIO-323 continuously for 6 weeks with/without the presence of particles, or for the initial 3 of 6 weeks had minor effects on bone ingrowth. After establishing a particle-induced chronic inflammatory reaction for 3 weeks, administration of SCIO-323 for a subsequent 3 weeks suppressed net bone formation. The activity of osteoclast-like cells remained low among all treatments when compared with the first control.[1]
Chemical Properties
Molecular Weight479.54
FormulaC27H30FN3O4
Cas No.309913-51-7
SmilesC(C(N(C)C)=O)(=O)C=1C=2C(=CC(OC)=C(C(=O)N3CCC(CC4=CC=C(F)C=C4)CC3)C2)N(C)C1
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (57.35 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0853 mL10.4267 mL20.8533 mL104.2666 mL
5 mM0.4171 mL2.0853 mL4.1707 mL20.8533 mL
10 mM0.2085 mL1.0427 mL2.0853 mL10.4267 mL
20 mM0.1043 mL0.5213 mL1.0427 mL5.2133 mL
50 mM0.0417 mL0.2085 mL0.4171 mL2.0853 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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