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Sclareol
🥰Excellent
Catalog No. T3020Cas No. 515-03-7
Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.
Sclareol
🥰Excellent
Purity: 99.58%
Catalog No. T3020Cas No. 515-03-7
Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $38 | In Stock | |
| 50 mg | $53 | In Stock | |
| 100 mg | $74 | In Stock | |
| 500 mg | $173 | In Stock |
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Purity:99.58%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines. |
| In vitro | Ingestion of Sclareol in rats demonstrates an LD50 greater than 5 g/kg. |
| In vivo | Sclareol inhibits DNA synthesis in human breast cancer cell lines, inducing apoptosis that does not depend on p53 and causing cell cycle arrest at the G(0/1) phase. Intratumoral injection of Sclareol decreases in-vivo growth of breast cancer tumors. It demonstrates growth inhibition and cytotoxicity across various human cancer cell lines. Additionally, Sclareol exhibits anti-inflammatory activity in lipopolysaccharide-stimulated macrophages by reducing the expression of inflammatory cytokines and increasing the activity of antioxidant enzymes. |
| Molecular Weight | 308.5 |
| Formula | C20H36O2 |
| Cas No. | 515-03-7 |
| Smiles | C[C@]12[C@@](CC[C@@](C)(O)[C@@H]1CC[C@@](C=C)(C)O)(C(C)(C)CCC2)[H] |
| Relative Density. | 0.954 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 45 mg/mL (145.87 mM)  Ethanol: 23 mg/mL (74.6 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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