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SD-169

🥰Excellent
Catalog No. T7661Cas No. 1670-87-7
Alias SD 169

SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.

SD-169

SD-169

🥰Excellent
Purity: 98.60%
Catalog No. T7661Alias SD 169Cas No. 1670-87-7
SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.
Pack SizePriceAvailabilityQuantity
25 mg$31In Stock
50 mg$48In Stock
100 mg$73In Stock
200 mg$107In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:98.60%
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Product Introduction

Bioactivity
Description
SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.
Targets&IC50
p38α MAPK:3.2 nM (IC50), p38β MAPK:122 nM (IC50)
In vivo
Animals were gavaged with Scios SD-169 (10 or 30 mg/kg) or excipient (PEG300) 1 day before and daily after crush injury to the sciatic nerve.?SD-169 is a proprietary oral inhibitor of p38 MAPK activity.?The rate of axonal regeneration was determined by the functional pinch test and was significantly increased in treated animals 8 days after crush injury (P < 0.05;?30 mg/kg dose).?In SD-169-treated animals with nerve transection, nerve fibers regenerating through a silicone chamber were morphologically more mature than untreated nerves when observed 28 days after transection.?TNF immunofluorescence of distal nerve segments after crush injury suggested that SD-169 reduced SC TNF protein[1].
AliasSD 169
Chemical Properties
Molecular Weight160.17
FormulaC9H8N2O
Cas No.1670-87-7
SmilesNC(=O)c1ccc2[nH]ccc2c1
Relative Density.1.328g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (62.43 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.2434 mL31.2168 mL62.4337 mL312.1683 mL
5 mM1.2487 mL6.2434 mL12.4867 mL62.4337 mL
10 mM0.6243 mL3.1217 mL6.2434 mL31.2168 mL
20 mM0.3122 mL1.5608 mL3.1217 mL15.6084 mL
50 mM0.1249 mL0.6243 mL1.2487 mL6.2434 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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