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SD-169
Catalog No. T7661Cas No. 1670-87-7
SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $30 | In Stock | |
| 25 mg | $51 | In Stock | |
| 50 mg | $80 | In Stock | |
| 100 mg | $122 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor. |
| Targets&IC50 | p38β MAPK:122 nM (IC50), p38α MAPK:3.2 nM (IC50) |
| In vivo | Animals were gavaged with Scios SD-169 (10 or 30 mg/kg) or excipient (PEG300) 1 day before and daily after crush injury to the sciatic nerve.?SD-169 is a proprietary oral inhibitor of p38 MAPK activity.?The rate of axonal regeneration was determined by the functional pinch test and was significantly increased in treated animals 8 days after crush injury (P < 0.05;?30 mg/kg dose).?In SD-169-treated animals with nerve transection, nerve fibers regenerating through a silicone chamber were morphologically more mature than untreated nerves when observed 28 days after transection.?TNF immunofluorescence of distal nerve segments after crush injury suggested that SD-169 reduced SC TNF protein[1]. |
| Alias | SD 169 |
| Molecular Weight | 160.17 |
| Formula | C9H8N2O |
| Cas No. | 1670-87-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (62.43 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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