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SDMA

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Catalog No. T7344Cas No. 30344-00-4
Alias Symmetric dimethylarginine, NG,NG'-Dimethyl-L-arginine

SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).

SDMA

SDMA

🥰Excellent
Catalog No. T7344Alias Symmetric dimethylarginine, NG,NG'-Dimethyl-L-arginineCas No. 30344-00-4
SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).
Pack SizePriceAvailabilityQuantity
5 mg32 €In Stock
10 mg52 €In Stock
25 mg95 €In Stock
50 mg165 €In Stock
100 mg260 €In Stock
1 mL x 10 mM (in DMSO)47 €In Stock
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Purity:≥98%
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Product Introduction

Bioactivity
Description
SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD).
In vitro
SDMA inhibited dose dependently the NO synthesis in intact endothelial cells, whereas it had no effect on protein expression of NOS. This effect was associated with an increase in reactive oxygen species. Co-incubation with L-arginine but not D-arginine reversed the effect of SDMA on NOS pathway. Suggest that SDMA reduced the endothelial NO synthesis, probably by limiting L-arginine supply to NOS. It is concluded that SDMA might be a useful parameter for detecting patients in very early stages of chronic kidney disease and for determining their risk for developing cardiovascular disease[1].
AliasSymmetric dimethylarginine, NG,NG'-Dimethyl-L-arginine
Chemical Properties
Molecular Weight202.25
FormulaC8H18N4O2
Cas No.30344-00-4
SmilesCNC(NC)=NCCC[C@H](N)C(O)=O
Relative Density.1.22 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (247.22 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.9444 mL24.7219 mL49.4438 mL247.2188 mL
5 mM0.9889 mL4.9444 mL9.8888 mL49.4438 mL
10 mM0.4944 mL2.4722 mL4.9444 mL24.7219 mL
20 mM0.2472 mL1.2361 mL2.4722 mL12.3609 mL
50 mM0.0989 mL0.4944 mL0.9889 mL4.9444 mL
100 mM0.0494 mL0.2472 mL0.4944 mL2.4722 mL

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