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SJ-172550
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
Catalog No. T16888Cas No. 431979-47-4
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Purity:99.87%
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SJ-172550
Catalog No. T16888Cas No. 431979-47-4
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $35 | In Stock | |
| 10 mg | $58 | In Stock | |
| 25 mg | $117 | In Stock | |
| 50 mg | $223 | In Stock | |
| 100 mg | $383 | In Stock | |
| 200 mg | $537 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM). |
| Targets&IC50 | MDMX:5 μM |
| In vitro | SJ-172550 interacts with the p53-binding pocket of MDMX, effectively displacing p53 and reversibly binding to MDMX, resulting in the death of retinoblastoma cells with amplified MDMX expression. This compound establishes a covalent, yet reversible, complex with MDMX, which prohibits MDMX from binding to p53. The efficacy of SJ-172550 is enhanced when used in conjunction with the MDM2 inhibitor, nutlin-3a. The stability of the SJ-172550/MDMX complex is dependent on several factors, such as the media's reducing potential and the presence of aggregates. |
| Molecular Weight | 428.87 |
| Formula | C22H21ClN2O5 |
| Cas No. | 431979-47-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33.33 mg/mL (77.72 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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