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SKF-83566 hydrochloride is a D1-like dopamine receptor antagonist that can cross the blood-brain barrier and is orally active. It inhibits the dopamine transporter, reduces the conditioned place preference (CPP) induced by GBP, and can be used in the study of neurological diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $45 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $156 | In Stock | |
25 mg | $350 | In Stock | |
50 mg | $660 | In Stock |
Description | SKF-83566 hydrochloride is a D1-like dopamine receptor antagonist that can cross the blood-brain barrier and is orally active. It inhibits the dopamine transporter, reduces the conditioned place preference (CPP) induced by GBP, and can be used in the study of neurological diseases. |
Targets&IC50 | DAT:5.7 μM |
In vitro | SKF-83566 hydrochloride is a competitive dopamine transporter (DAT) inhibitor with an IC50 of 5.7 μM. [1] SKF-83566 hydrochloride acts on the vascular 5-HT2 receptor (Ki=11 nM). [2] |
In vivo | Combined administration of SKF-83566 hydrochloride (0.15 mg/kg/mL) and A68930 (0.4 mg/kg/mL) prevented glutamate-based long-term enhancement (LTP) in the medial prefrontal cortex mPFC and led to long-term depression induced by high frequency stimulation (HFS). [3] |
Alias | SKF-83566 hydrochloride(99295-33-7 Free base) |
Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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