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SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $53 | In Stock | |
2 mg | $76 | In Stock | |
5 mg | $155 | In Stock | |
10 mg | $273 | In Stock | |
25 mg | $465 | In Stock | |
50 mg | $682 | In Stock | |
1 mL x 10 mM (in DMSO) | $163 | In Stock |
Description | SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ). |
Targets&IC50 | Rev-Erb:790 nM, Rev-Erbα:560 nM |
In vitro | SR9011 and SR9009 effectively inhibits transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50: 620 nM). SR9011 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner. |
In vivo | SR9011 inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2: Luc reporter mouse. |
Molecular Weight | 479.04 |
Formula | C23H31ClN4O3S |
Cas No. | 1379686-29-9 |
Smiles | CCCCCNC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1 |
Relative Density. | 1.254 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (104.38 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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