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SR9011

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Purity:99.65%

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COA HPLC HNMR

SR9011

Catalog No. T3688Cas No. 1379686-29-9

SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).

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Pack Size	Price	Availability
1 mg	$53	In Stock
2 mg	$76	In Stock
5 mg	$155	In Stock
10 mg	$273	In Stock
25 mg	$465	In Stock
50 mg	$682	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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Product Introduction

Bioactivity

Description	SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
In vitro	SR9011 and SR9009 effectively inhibits transcription in a cotransfection assay using full-length REV-ERBα along with a luciferase reporter driven by the Bmal1 promoter (SR9011 IC50: 620 nM). SR9011 suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
In vivo	SR9011 inhibits the activity of the SCN clock, with reversible inhibition of circadian oscillations in SCN explants cultured from the Per2: Luc reporter mouse.

Chemical Properties

Molecular Weight	479.04
Formula	C23H31ClN4O3S
Cas No.	1379686-29-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (104.38 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0875 mL	10.4375 mL	20.8751 mL	104.3754 mL
5 mM	0.4175 mL	2.0875 mL	4.1750 mL	20.8751 mL
10 mM	0.2088 mL	1.0438 mL	2.0875 mL	10.4375 mL
20 mM	0.1044 mL	0.5219 mL	1.0438 mL	5.2188 mL
50 mM	0.0418 mL	0.2088 mL	0.4175 mL	2.0875 mL
100 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0438 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc