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SRX3207
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
Catalog No. T22430Cas No. 2254693-15-5
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Purity:98.14%
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SRX3207
Catalog No. T22430Cas No. 2254693-15-5
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $85 | In Stock | |
| 5 mg | $217 | In Stock | |
| 10 mg | $325 | In Stock | |
| 25 mg | $526 | In Stock | |
| 50 mg | $693 | In Stock | |
| 100 mg | $972 | In Stock | |
| 500 mg | $1,950 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression. |
| Targets&IC50 | PI3Kα:861 nM (IC50), PI3Kγ:11100 nM (IC50), ZAP70:1300 nM (IC50), Syk:10.7 nM (IC50), PI3Kδ:1280 nM (IC50) |
| In vitro | The IC50 values are 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 (10 μmol/L) blocks p-AKT[1]. |
| In vivo | Oral administration of SRX3207 increases antitumor immune response. SRX3207 blocks immunosuppressive MΦ polarization, blocks tumor growth, and increases survival effectively[1]. |
| Molecular Weight | 555.65 |
| Formula | C29H29N7O3S |
| Cas No. | 2254693-15-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (8.1 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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