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ST-193
🥰Excellent
Catalog No. T13006Cas No. 489416-12-8
ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).
ST-193
🥰Excellent
Purity: 99.67%
Catalog No. T13006Cas No. 489416-12-8
ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 45 € | In Stock | |
| 5 mg | 112 € | In Stock | |
| 10 mg | 169 € | In Stock | |
| 25 mg | 305 € | In Stock | |
| 50 mg | 426 € | In Stock | |
| 100 mg | 598 € | In Stock | |
| 200 mg | 805 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 123 € | In Stock |
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CitedSelect Batch
Purity:99.67%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively). |
| Targets&IC50 | Lassa:1.4 nM , Guanarito:0.44 nM , Machupo:3.1 nM , Junin:0.62 nM |
| In vitro | LASV pseudotypes(IC50 of 1.6 nM)inhibited by ST-193 . ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for JunÃn, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range)[2]. |
| In vivo | ST-193, exhibits submicromolar antiviral activity in vitro.?To determine the antiviral utility of ST-193 in vivo, Tested the efficacy of this compound in the LASV guinea pig model.?Four groups of strain 13 guinea pigs were administered 25 or 80 mg/kg ST-193, 25 mg/kg of ribavirin, or the vehicle by the intraperitoneal (i.p.) route before infection with a lethal dose of LASV, strain Josiah, and continuing once daily for 14 days.?Control animals exhibited severe disease, becoming moribund between days 10 and 15 postinfection.?ST-193-treated animals exhibited fewer signs of disease and enhanced survival when compared to the ribavirin or vehicle groups.?Body temperatures in all groups were elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals.?ST-193 treatment mediated a 2-3-log reduction in viremia relative to vehicle-treated controls.?The overall survival rate for the ST-193-treated guinea pigs was 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups.?These data suggest that ST-193 may serve as an improved candidate for the treatment of Lassa fever[3]. |
| Molecular Weight | 371.47 |
| Formula | C24H25N3O |
| Cas No. | 489416-12-8 |
| Smiles | COc1ccc(cc1)-n1cnc2cc(NCc3ccc(cc3)C(C)C)ccc12 |
| Relative Density. | 1.12 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (403.80 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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