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STX-0119
🥰Excellent
Catalog No. T60160Cas No. 851095-32-4
STX-0119 is a selective, orally active STAT3 dimerization inhibitor that suppresses STAT3 transcription with an IC50 of 74 μM.
STX-0119
🥰Excellent
Purity: 99.42%
Catalog No. T60160Cas No. 851095-32-4
STX-0119 is a selective, orally active STAT3 dimerization inhibitor that suppresses STAT3 transcription with an IC50 of 74 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $58 | In Stock | |
| 10 mg | $93 | In Stock | |
| 25 mg | $187 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $448 | In Stock | |
| 500 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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CitedSelect Batch
Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | STX-0119 is a selective, orally active STAT3 dimerization inhibitor that suppresses STAT3 transcription with an IC50 of 74 μM. |
| In vitro | STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through direct interaction with the STAT3 protein, without affecting upstream regulators like JAK, in HEK293 and MDA-MB-468 cells, and reduces the expression of STAT3 target proteins[1]. |
| In vivo | STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice, with plasma concentrations maintained above 100 μg/mL (>260 μM) 8 hours post-administration[1]. |
| Molecular Weight | 382.37 |
| Formula | C22H14N4O3 |
| Cas No. | 851095-32-4 |
| Smiles | C(NC=1OC(=NN1)C2=CC=CO2)(=O)C=3C4=C(N=C(C3)C5=CC=CC=C5)C=CC=C4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (143.84 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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