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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $338 | In Stock | |
5 mg | $859 | In Stock | |
10 mg | $1,360 | In Stock | |
25 mg | $2,770 | In Stock | |
50 mg | $4,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $758 | In Stock |
Description | STX-478 is an orally active and selective PI3Kα inhibitor that penetrates the blood-brain barrier and has anticancer activity to inhibit tumor growth.STX-478 is indicated for the study of breast cancer and other cancers. |
In vitro | STX-478 ( 0-10,000 nM ; 1 h ) targeted the MCF10A cells ( with the H1047R kinase domain mutation )[1]. |
In vivo | In Female BALB/c nude mice (CAL-33 xenograft model), STX-478 (30, 100 mg/kg; oral administration) showed a dose-dependent reduction in tumor volume[1]. |
Molecular Weight | 401.29 |
Formula | C16H12F5N5O2 |
Cas No. | 2883540-92-7 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (249.20 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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