TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.

TABERSONINE HYDROCHLORIDE is an indole alkaloid mainly isolated from Catharanthus roseus, and a potential drug candidate for treatment of cancer and Alzheimer's disease (AD), however, its anti-inflammatory effect has not been revealed.TABERSONINE HYDROCHLORIDE ameliorated lipopolysaccharides (LPS)-induced ALI in vivo and inhibited LPS-mediated macrophage activation in vitro. By using murine ALI model, we found that TABERSONINE HYDROCHLORIDE significantly attenuated LPS-induced pathological injury in the lung. TABERSONINE HYDROCHLORIDE also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-α, IL-6 and IL-1β. Furthermore, TABERSONINE HYDROCHLORIDE inhibited LPS-induced the production of pro-inflammatory mediators such as iNOS, NO and cytokines by suppressing NF-κB and p38 MAPK/MK2 signaling cascades. TABERSONINE HYDROCHLORIDE HYDROCHLORIDE reduced the K63-linked polyubiquitination of TRAF6. Taken together,TABERSONINE HYDROCHLORIDE has anti-inflammatory activities in vitro and in vivo, and is a potential therapeutic candidate for the treatment of ALI/ARDS[1].