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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $49 | In Stock | |
5 mg | $109 | In Stock | |
10 mg | $135 | In Stock | |
25 mg | $298 | In Stock | |
50 mg | $433 | In Stock | |
100 mg | $592 | In Stock | |
500 mg | $1,180 | In Stock |
Description | Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo. |
In vitro | Talibegron hydrochloride ( 0.01-1000 μM) produces a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries and causes full relaxation with 1 mM[1]. |
In vivo | The β3-adrenoceptor agonist talibegron hydrochloride produced a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries. The shape of the concentration–response curve of talibegron hydrochloride also suggests that this drug, which was studied up to 1 mm, causes full relaxation [3]. |
Alias | ZD2079 hydrochloride, ZD 2079 |
Molecular Weight | 351.83 |
Formula | C18H22ClNO4 |
Cas No. | 178600-17-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: < 8.8 mg/mL DMSO: 50 mg/mL (142.11 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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