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Tandospirone
🥰Excellent
Catalog No. TQ0315Cas No. 87760-53-0
Alias SM-3997, SM3997
Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders.
Tandospirone
🥰Excellent
Catalog No. TQ0315Alias SM-3997, SM3997Cas No. 87760-53-0
Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $30 | In Stock | |
| 5 mg | $48 | In Stock | |
| 10 mg | $77 | In Stock | |
| 25 mg | $139 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $316 | In Stock | |
| 200 mg | $453 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $53 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders. |
| Targets&IC50 | brain hippocampal membranes (rat):9.4 nM (Kd), brain hippocampal membranes (rat):213 fmol/mg (Bmax) |
| In vitro | Tandospirone has negligible effects at 5-HT1B receptors, 5-HT uptake sites, β-adrenergic receptors, muscarinic cholinergic receptors, and benzodiazepine receptors. [1]3H-Tandospirone rapidly binds to rat brain hippocampal membranes and achieves binding in a high-affinity, reversible, and saturating fashion (Kd: 9.4 nM, Bmax: 213 fmol/mg protein). [2] |
| In vivo | Chronic administration of Tandospirone (0.2 and 1.0 mg/kg/day, but not 2.0 mg/kg/day) was effective in alleviating elevated levels of eLAC in the anterior cingulate cortex (mPFC) due to foot shock stress. [3] After acute administration of Tandospirone (0, 0.1 and 1 mg/kg, intraperitoneally) to rats, a significant reduction in the number of premature responses in a dose-dependent manner was observed, an index used to assess impulsive behavior. [4] |
| Alias | SM-3997, SM3997 |
| Molecular Weight | 383.49 |
| Formula | C21H29N5O2 |
| Cas No. | 87760-53-0 |
| Smiles | O=C1[C@]2([C@]([C@]3(C[C@@]2(CC3)[H])[H])(C(=O)N1CCCCN4CCN(CC4)C=5N=CC=CN5)[H])[H] |
| Relative Density. | 1.239g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble) DMSO: 15.00 mg/mL (39.11 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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