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TAS-119
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TAS-119
Catalog No. T34787Cas No. 1453099-83-6
TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $397 | In Stock | |
| 25 mg | $788 | In Stock | |
| 50 mg | $1,230 | In Stock | |
| 100 mg | $1,730 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $275 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity. |
| In vitro | TAS-119 (30-300 nM) dose-dependently augments the growth inhibition of HeLa cells induced by three taxanes (Paclitaxel, Docetaxel, and Cabazitaxel). It specifically promotes mitotic accumulation in tumor cells over normal diploid fibroblasts. Moreover, TAS-119 amplifies the antiproliferative efficacy of Paclitaxel across a diverse array of human cancer cell lines, even those resistant to Paclitaxel.[1] |
| In vivo | TAS-119 (5, 10, and 30 mg/kg; oral; twice daily on day 1 and every day on day 2; Nude rats injected with HeLa-luc cells) induced pHH3 at all doses in nude rats with the HeLa-luc xenografts. The treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts.[1] |
| Alias | TAS119, TAS2104, TAS 2104, TAS-2104, TAS 119 |
| Molecular Weight | 506.36 |
| Formula | C23H22Cl2FN5O3 |
| Cas No. | 1453099-83-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (88.87 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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