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Tecadenoson

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Purity:99.76%

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COA HNMR HPLC

Tecadenoson

Catalog No. T17023Cas No. 204512-90-3

Tecadenoson (CVT-510) is a selective agonist of A1 adenosine receptor.

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Pack Size	Price	Availability
1 mg	$96	In Stock
2 mg	$142	In Stock
5 mg	$239	In Stock
10 mg	$378	In Stock
25 mg	$639	In Stock
50 mg	$913	In Stock
100 mg	$1,230	In Stock
500 mg	$2,490	In Stock
1 mL x 10 mM (in DMSO)	$263	In Stock

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Product Introduction

Bioactivity

Description	Tecadenoson (CVT-510) is a selective agonist of A1 adenosine receptor.
In vitro	Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41?nM) than to increase coronary conductance (EC50=200?nM) in the atrial-paced isolated heart. Tecadenoson shortens atrial (EC50=73?nM) but not the ventricular monophasic action potentials (MAP). At concentrations of Tecadenoson (40?nM) and diltiazem (1?μM) that induces equal prolongation of S-H interval (～10?ms), diltiazem, but not Tecadenoson, significantly decreases left ventricular developed pressure (LVP) and markedly increases coronary conductance [1].
In vivo	Intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval In atrial-paced anaesthetized guinea-pigs. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson (50 μg/kg) treatment induces a significant bradycardia (50% decrease in heart rate at 25 min) [1][2].
Alias	CVT-510

Chemical Properties

Molecular Weight	337.33
Formula	C14H19N5O5
Cas No.	204512-90-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 155 mg/mL (459.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9645 mL	14.8223 mL	29.6446 mL	148.2228 mL
5 mM	0.5929 mL	2.9645 mL	5.9289 mL	29.6446 mL
10 mM	0.2964 mL	1.4822 mL	2.9645 mL	14.8223 mL
20 mM	0.1482 mL	0.7411 mL	1.4822 mL	7.4111 mL
50 mM	0.0593 mL	0.2964 mL	0.5929 mL	2.9645 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4822 mL

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