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Terbogrel
🥰Excellent
Catalog No. T17039Cas No. 149979-74-8
Alias BIBV 308SE
Terbogrel is an oral thromboxane A2 receptor antagonist (IC50 is about 10 nM) and thromboxane A2 synthase inhibitor (IC50 is about 10 nM). Terbogrel is an antiplatelet compound that inhibits platelet aggregation and is a potential compound for the prevention of blood clots.
Terbogrel
🥰Excellent
Purity: 99.65%
Catalog No. T17039Alias BIBV 308SECas No. 149979-74-8
Terbogrel is an oral thromboxane A2 receptor antagonist (IC50 is about 10 nM) and thromboxane A2 synthase inhibitor (IC50 is about 10 nM). Terbogrel is an antiplatelet compound that inhibits platelet aggregation and is a potential compound for the prevention of blood clots.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $117 | In Stock | |
| 5 mg | $279 | In Stock | |
| 10 mg | $407 | In Stock | |
| 25 mg | $642 | In Stock | |
| 50 mg | $858 | In Stock | |
| 100 mg | $1,150 | In Stock | |
| 200 mg | $1,560 | In Stock |
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Purity:99.65%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Terbogrel is an oral thromboxane A2 receptor antagonist (IC50 is about 10 nM) and thromboxane A2 synthase inhibitor (IC50 is about 10 nM). Terbogrel is an antiplatelet compound that inhibits platelet aggregation and is a potential compound for the prevention of blood clots. |
| Targets&IC50 | TXA2 receptor:apr 10 nM, TXA2 synthase:appr 10 nM |
| In vitro | Terbogrel inhibits collagen-induced platelet aggregation in human platelet-rich plasma and whole blood (IC50: 310 ± 18 nM (n = 8) and 52 ± 20 nM (n = 6), respectively). Terbogrel (1 μM) fully inhibits U46619-induced platelet aggregation (IC50: 10 nM). Pretreatment of platelets with terbogrel (1 μM) completely inhibits thrombin-induced thromboxane A2 formation (2±1 ng/mL) but does not result in any inhibition of platelet aggregation. Terbogrel blocks the thromboxane A2/endoperoxide receptor on washed human platelets (IC50: 11 ± 6 nM (n = 2) and IC50: 38 ± 1 nM (n = 15) in platelet-rich plasma).[1][2] |
| In vivo | Terbogrel (10 mg/kg, p.o.) is rapidly and well (90%) absorbed with a systemic availability of about 30% in rats. Terbogrel (0.1-3.0 mg/kg) shows an impressive antithrombotic efficacy in rabbits.[2] |
| Alias | BIBV 308SE |
| Molecular Weight | 405.49 |
| Formula | C23H27N5O2 |
| Cas No. | 149979-74-8 |
| Smiles | C(=C\CCCC(O)=O)(\C1=CC(N=C(NC(C)(C)C)NC#N)=CC=C1)/C=2C=CC=NC2 |
| Relative Density. | 1.13g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (67.82 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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