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TG6-129

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COA LCMS HNMR

TG6-129

Catalog No. T28958Cas No. 1164464-14-5

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages.

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Pack Size	Price	Availability
1 mg	$123	In Stock
5 mg	$253	In Stock
10 mg	$449	In Stock
25 mg	$739	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
500 mg	$2,820	In Stock
1 mL x 10 mM (in DMSO)	$357	In Stock

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Product Introduction

Bioactivity

Description	TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and TNF-α induced by the EP2-selective
Alias	TG6 129

Chemical Properties

Molecular Weight	491.58
Formula	C20H18FN5O3S3
Cas No.	1164464-14-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (111.88 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0343 mL	10.1713 mL	20.3426 mL	101.7128 mL
5 mM	0.4069 mL	2.0343 mL	4.0685 mL	20.3426 mL
10 mM	0.2034 mL	1.0171 mL	2.0343 mL	10.1713 mL
20 mM	0.1017 mL	0.5086 mL	1.0171 mL	5.0856 mL
50 mM	0.0407 mL	0.2034 mL	0.4069 mL	2.0343 mL
100 mM	0.0203 mL	0.1017 mL	0.2034 mL	1.0171 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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