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Thiomyristoyl
🥰Excellent
Catalog No. T3447Cas No. 1429749-41-6
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
Thiomyristoyl
🥰Excellent
Purity: 99.13%
Catalog No. T3447Cas No. 1429749-41-6
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 2 mg | $70 | In Stock | |
| 5 mg | $88 | In Stock | |
| 10 mg | $126 | In Stock | |
| 25 mg | $239 | In Stock | |
| 50 mg | $401 | In Stock | |
| 100 mg | $597 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $126 | In Stock |
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Purity:99.13%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
| Targets&IC50 | SIRT2:28 nM |
| In vitro | In a breast cancer mouse model, Thiomyristoyl inhibits SIRT2 and tumor growth, while also reducing the levels of the c-Myc protein. The anticancer effects of Thiomyristoyl are positively correlated with the reduction of c-Myc levels. |
| In vivo | Thiomyristoyl exhibits weak inhibition towards SIRT3/5/6/7. It can reduce the level of c-MYC in cancer cells in vitro, with the extent of c-MYC reduction directly proportional to the cell line’s sensitivity to Thiomyristoyl. |
| Cell Research | Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control. (Only for Reference) |
| Molecular Weight | 581.85 |
| Formula | C34H51N3O3S |
| Cas No. | 1429749-41-6 |
| Smiles | CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1 |
| Relative Density. | 1.077 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (171.87 mM) Chloroform: Soluble H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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