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THZ-P1-2
🥰Excellent
Catalog No. T39459Cas No. 2058075-45-7
THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.THZ-P1-2 induces cell death and mitochondrial damage, and can be used in the study of leukemias.
THZ-P1-2
🥰Excellent
Catalog No. T39459Cas No. 2058075-45-7
THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.THZ-P1-2 induces cell death and mitochondrial damage, and can be used in the study of leukemias.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $148 | In Stock | |
| 5 mg | $372 | In Stock | |
| 10 mg | $579 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,350 | In Stock | |
| 100 mg | $1,830 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.THZ-P1-2 induces cell death and mitochondrial damage, and can be used in the study of leukemias. |
| In vitro | THZ-P1-2 (0.2-11.4 μM) exhibits approximately 75% inhibition of PI-4,5-P2 formation by PI5P4Kα and PI5P4Kγ and 50% inhibition by PI5P4Kβ at 0.7 μM[1]. THZ-P1-2 (10-100000 nM; 72 hours) demonstrates modest anti-proliferative activity across six AML/ALL cell lines, with IC50 values ranging from 0.87 to 3.95 μM[1]. Cell Proliferation Assay[1]Cell Line: THP1, SEMK2, OCI/AML-2, HL60, SKM1, NOMO1 cells. Concentration: 10-100000 nM. Incubation Time: 72 hours. Result: Anti-proliferative activity with IC50 values from 0.87 to 3.95 μM. |
| Molecular Weight | 531.61 |
| Formula | C31H29N7O2 |
| Cas No. | 2058075-45-7 |
| Smiles | CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (150.49 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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