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Tiludronate disodium

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Purity:100%

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COA LCMS HNMR HPLC

Tiludronate disodium

Catalog No. T13159Cas No. 149845-07-8

Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.

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Pack Size	Price	Availability
5 mg	$73	In Stock
10 mg	$117	In Stock
25 mg	$198	In Stock
50 mg	$297	In Stock
100 mg	$441	In Stock
500 mg	$888	In Stock

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Product Introduction

Bioactivity

Description	Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
In vitro	Tiludronate displays potent inhibitory against proton transport in yeast microsomal preparations with an IC50 of 3.5 μM and inhibits the activity of purified yeast V-ATPase. Tiludronate inhibits proton transport with IC50s of 1.1 mM and 466 nM in kidney-derived vesicles and vesicles derived from osteoclasts[3].
In vivo	Tiludronate dose-dependently inhibits the resorption of bones. Tiludronate reduces the secrete proton of mature osteoclasts into the resorption space and favors the detachment of mature osteoclasts from the bone matrix. Oral administration of Tiludronate (5-200 mg/kg) prevents the decrease in the skeletal mass in the castrated male rat model[3].
Alias	Tiludronic Acid disodium, Tiludronic acid disodium

Chemical Properties

Molecular Weight	362.57
Formula	C7H7ClNa2O6P2S
Cas No.	149845-07-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 56.2 mg/mL (155.1 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7581 mL	13.7904 mL	27.5809 mL	137.9044 mL
5 mM	0.5516 mL	2.7581 mL	5.5162 mL	27.5809 mL
10 mM	0.2758 mL	1.3790 mL	2.7581 mL	13.7904 mL
20 mM	0.1379 mL	0.6895 mL	1.3790 mL	6.8952 mL
50 mM	0.0552 mL	0.2758 mL	0.5516 mL	2.7581 mL
100 mM	0.0276 mL	0.1379 mL	0.2758 mL	1.3790 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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