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TUG-891
🥰Excellent
Catalog No. T3433Cas No. 1374516-07-0
Alias TUG891, TUG 891
TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
TUG-891
🥰Excellent
Purity: 99.21%
Catalog No. T3433Alias TUG891, TUG 891Cas No. 1374516-07-0
TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 2 mg | $47 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $117 | In Stock | |
| 25 mg | $237 | In Stock | |
| 50 mg | $397 | In Stock | |
| 100 mg | $582 | In Stock | |
| 500 mg | $1,230 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $85 | In Stock |
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Purity:99.21%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. |
| In vitro | TUG-891 exhibits analogous signaling characteristics to the long-chain fatty acid (LCFA) α-linolenic acid at the human Free Fatty Acid receptor 4 (FFA4), stimulating Ca2+ mobilization, recruiting β-arrestin-1 and β-arrestin-2, and promoting extracellular signal-regulated kinase phosphorylation. Moreover, TUG-891 activation of FFA4 leads to the receptor's swift phosphorylation and internalization[1]. |
| Kinase Assay | Inhibition of recombinant human Mps1 by BAY 1161909 or BAY 1217389 is assessed in TRFRET-based in vitro kinase assays via phosphorylation of a biotinylated peptide (Biotin-Ahx-PWDPDDADITEILG-NH2). Under standard assay conditions kinase and test compound are preincubated for 15 min before enzyme reaction is started by addition of substrate and ATP upon 10 μM[1]. |
| Alias | TUG891, TUG 891 |
| Molecular Weight | 364.41 |
| Formula | C23H21FO3 |
| Cas No. | 1374516-07-0 |
| Smiles | C(OC1=CC=C(CCC(O)=O)C=C1)C2=C(C=CC(F)=C2)C3=CC=C(C)C=C3 |
| Relative Density. | 1.199 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (109.77 mM)  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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