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TUG-891

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Purity:99.21%

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COA HPLC HNMR

TUG-891

Catalog No. T3433Cas No. 1374516-07-0

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$47	In Stock
5 mg	$77	In Stock
10 mg	$117	In Stock
25 mg	$237	In Stock
50 mg	$397	In Stock
100 mg	$582	In Stock
500 mg	$1,230	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock

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Product Introduction

Bioactivity

Description	TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
In vitro	TUG-891 exhibits analogous signaling characteristics to the long-chain fatty acid (LCFA) α-linolenic acid at the human Free Fatty Acid receptor 4 (FFA4), stimulating Ca2+ mobilization, recruiting β-arrestin-1 and β-arrestin-2, and promoting extracellular signal-regulated kinase phosphorylation. Moreover, TUG-891 activation of FFA4 leads to the receptor's swift phosphorylation and internalization[1].
Kinase Assay	Inhibition of recombinant human Mps1 by BAY 1161909 or BAY 1217389 is assessed in TRFRET-based in vitro kinase assays via phosphorylation of a biotinylated peptide (Biotin-Ahx-PWDPDDADITEILG-NH2). Under standard assay conditions kinase and test compound are preincubated for 15 min before enzyme reaction is started by addition of substrate and ATP upon 10 μM[1].
Alias	TUG 891, TUG891

Chemical Properties

Molecular Weight	364.41
Formula	C23H21FO3
Cas No.	1374516-07-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (109.77 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7442 mL	13.7208 mL	27.4416 mL	137.2081 mL
5 mM	0.5488 mL	2.7442 mL	5.4883 mL	27.4416 mL
10 mM	0.2744 mL	1.3721 mL	2.7442 mL	13.7208 mL
20 mM	0.1372 mL	0.6860 mL	1.3721 mL	6.8604 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7442 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3721 mL

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