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UCB7362
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Catalog No. T69567Cas No. 2610631-17-7
Alias GLXC-26743
UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.
UCB7362
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Purity: 97.38%
Catalog No. T69567Alias GLXC-26743Cas No. 2610631-17-7
UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $579 | In Stock | |
| 5 mg | $1,270 | In Stock | |
| 25 mg | $1,980 | In Stock | |
| 50 mg | $2,580 | In Stock | |
| 100 mg | $3,400 | 8-10 weeks |
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Purity:97.38%
ee:95.03%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction. |
| Targets&IC50 | PMX:7 nM, PMIX:142 nM |
| In vitro | UCB7362 exhibits significantly higher potency against PMX than PMIX, with an IC50 of 7 nM for the former compared to 142 nM for the latter[1]. Additionally, UCB7362 demonstrates improved selectivity against Cat D and Renin, with an IC50 of 3889 nM and >10,000 nM, respectively[1]. |
| In vivo | UCB7362, when administered orally at doses ranging from 10 to 60 mg/kg twice a day for 4 days, clears parasitemia from peripheral blood[1]. Furthermore, when given intravenously (IV) at 1 mg/kg and orally (PO) at 10 mg/kg in a single administration, UCB7362 exhibits moderate clearance in dogs and cynomolgus monkeys, and moderate to high clearance in rats[1]. |
| Alias | GLXC-26743 |
| Molecular Weight | 479.96 |
| Formula | C25H26ClN5O3 |
| Cas No. | 2610631-17-7 |
| Smiles | C[C@]1(CC(=O)N(C(N)=N1)[C@H]2C[C@@H](C)OCC2)C3=C(Cl)C(NC(=O)C4=CC(C#N)=CC=C4)=CC=C3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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