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UNC0646

🥰Excellent
Catalog No. TQ0232Cas No. 1320288-17-2
Alias UNC 0646

UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells) and exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).

UNC0646

UNC0646

🥰Excellent
Purity: 100%
Catalog No. TQ0232Alias UNC 0646Cas No. 1320288-17-2
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells) and exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
Pack SizePriceAvailabilityQuantity
5 mg$58In Stock
10 mg$103In Stock
25 mg$192In Stock
50 mg$342In Stock
100 mg$497In Stock
1 mL x 10 mM (in DMSO)$88In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells) and exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
Targets&IC50
G9a:6 nM, GLP:15 nM
AliasUNC 0646
Chemical Properties
Molecular Weight621.9
FormulaC36H59N7O2
Cas No.1320288-17-2
SmilesCOc1cc2c(NC3CCN(CC3)C3CCCCC3)nc(nc2cc1OCCCN1CCCCC1)N1CCCN(CC1)C(C)C
Relative Density.1.128 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (48.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6080 mL8.0399 mL16.0798 mL80.3988 mL
5 mM0.3216 mL1.6080 mL3.2160 mL16.0798 mL
10 mM0.1608 mL0.8040 mL1.6080 mL8.0399 mL
20 mM0.0804 mL0.4020 mL0.8040 mL4.0199 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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