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Usmarapride free base (SUVN-D4010 free base) is a selective and orally active 5-HT4 receptor partial agonist, increasing soluble amyloid precursor protein α levels, useful in Alzheimer's disease research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,270 | 6-8 weeks | |
50 mg | $1,650 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Usmarapride free base (SUVN-D4010 free base) is a selective and orally active 5-HT4 receptor partial agonist, increasing soluble amyloid precursor protein α levels, useful in Alzheimer's disease research. |
Targets&IC50 | 5-HT4 receptor:44 nM (EC50) |
In vivo | Methods: Usmarapride free base (1 mg/kg, oral and 1 mg/kg, intravenous) was administered to male beagle dogs to evaluate the pharmacokinetics of Usmarapride free base. Results: Usmarapride free base was rapidly absorbed after oral administration (Tmax in the range of 0.5-0.75 hours), with oral exposure (AUC0-24h = 711 ± 369 ng·h/mL) and showed a long terminal venous half-life (6.0 ± 1.5 hours), moderate venous clearance (18 ± 6 mL/min/ kg) and volume of distribution (5.1 ± 0.6 L/kg), and an absolute oral bioavailability (%F) of 72 ± 11%.[1] |
Alias | SUVN-D4010 free base, SUVN-D-1208045 free base, SUVN-D1003019 free base, SUVN-D 4010 free base, SUVN-1004028 free base, SUVN D4010 free base |
Molecular Weight | 383.49 |
Formula | C21H29N5O2 |
Cas No. | 1428862-32-1 |
Smiles | N=1N=C(OC1C2=NN(C=3C=CC=CC23)C(C)C)C4CCN(CCCOC)CC4 |
Relative Density. | 1.26 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (208.61 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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