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USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $40 | In Stock | |
5 mg | $94 | In Stock | |
10 mg | $146 | In Stock | |
25 mg | $282 | In Stock | |
50 mg | $419 | In Stock | |
100 mg | $596 | In Stock |
Description | USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer. |
In vitro | USP22-IN-1 (USP22i-S02), as a USP22-specific inhibitor. (i)USP22i-S02 (10 ug/mL) inhibits Treg suppressive functions.[2] |
In vivo | USP22-IN-1 (USP22i-S02) (20 mg/kg; i.p.; twice a day for 5 days) inhibits tumor cell expression of PD-Ll, both of which enhance antitumor immune response. In addition, USP22i-S02 can directly inhibit tumor cell proliferation through USP22 suppression.[2] |
Molecular Weight | 338.41 |
Formula | C22H18N4 |
Cas No. | 309735-96-4 |
Smiles | N#Cc1c2CCCCc2c(Nc2ccccc2)n2c3ccccc3nc12 |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (14.77 mM), Sonication is recommended. Ethanol: 2.7 mg/mL (8.0 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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