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VULM 1457

🥰Excellent
Catalog No. T23521Cas No. 228544-65-8

VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells.

VULM 1457

VULM 1457

🥰Excellent
Purity: 99.92%
Catalog No. T23521Cas No. 228544-65-8
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells.
Pack SizePriceAvailabilityQuantity
1 mg$29In Stock
2 mg$39In Stock
5 mg$58In Stock
10 mg$98In Stock
25 mg$191In Stock
50 mg$347In Stock
100 mg$490In Stock
200 mg$689In Stock
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Purity:99.92%
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Product Introduction

Bioactivity
Description
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells.
In vitro
Preincubation of HepG2 cells with VULM1457 (0.1 μM) significantly reduced the specific [125I]AM binding on hypoxic cells with BmaxHypox being 127±10 and KD 0.06±0.11 nM. Preincubation of cells with VULM1457 (0.1 μM) significantly enhanced the number of cells (24.2±6 %) and higher concentrations of VULM1457 (1.0 and 10.0 μM) reduces the total number of cells[2]. In HepG2 cell lines, VULM1457 (0.03 μM; 0.1 μM) significantly down-regulated specific AM receptors on HepG2 cells, and reduced AM secretion of HepG2 cells exposed to hypoxia. VULM1457 negatively regulates cell proliferation induced by AM[2].
In vivo
In male Wistar rats, VULM 1457 protected the hearts of diabetic–hypercholesterolaemic rats against ischemia/reperfusion injury in vivo[1]. VULM 1457 (50 mg/kg/day) significantly decreases plasma total cholesterol levels (1.7±0.1 mM vs. 2.9±0.5 mM in diabetic–hypercholesterolaemic animals). The hypolipidaemic effect of VULM 1457 is also observed in the liver of DM-HCH rats (3.9±0.2 mg/g vs. 7.4±1.0 mg/g)[1].
Chemical Properties
Molecular Weight449.57
FormulaC25H27N3O3S
Cas No.228544-65-8
SmilesCC(C)c1cccc(C(C)C)c1NC(=O)Nc1ccc(Sc2ccc(cc2)[N+]([O-])=O)cc1
Relative Density.1.24 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (133.46 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2243 mL11.1217 mL22.2435 mL111.2174 mL
5 mM0.4449 mL2.2243 mL4.4487 mL22.2435 mL
10 mM0.2224 mL1.1122 mL2.2243 mL11.1217 mL
20 mM0.1112 mL0.5561 mL1.1122 mL5.5609 mL
50 mM0.0445 mL0.2224 mL0.4449 mL2.2243 mL
100 mM0.0222 mL0.1112 mL0.2224 mL1.1122 mL

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