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YLF-466D

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Purity:98.04%

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COA HNMR HPLC

YLF-466D

Catalog No. T13368Cas No. 1273323-67-3

YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.

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Pack Size	Price	Availability
1 mg	$52	In Stock
2 mg	$76	In Stock
5 mg	$127	In Stock
10 mg	$198	In Stock
25 mg	$349	In Stock
50 mg	$499	In Stock
100 mg	$690	In Stock
500 mg	$1,370	In Stock
1 mL x 10 mM (in DMSO)	$131	In Stock

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Product Introduction

Bioactivity

Description	YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.
In vitro	The study investigates the impact of YLF-466D on platelet AMPK activation and its potential to inhibit platelet aggregation. Activation of platelet AMPK by YLF-466D is confirmed through phosphorylation at Thr172, leading to the suppression of platelet aggregation triggered by thrombin, ADP, and collagen. This demonstrates that YLF-466D's anti-aggregatory effect is broad and not specific to the type of platelet agonist. The effects of YLF-466D on AMPK activation and aggregation inhibition are concentration-dependent, showing maximal effectiveness at 150 μM. The IC50 values for inhibiting aggregation induced by thrombin, ADP, and collagen are approximately 84, 55, and 87 μM, respectively.
Alias	C24

Chemical Properties

Molecular Weight	465.93
Formula	C29H20ClNO3
Cas No.	1273323-67-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90mg/mL (193.2mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1462 mL	10.7312 mL	21.4625 mL	107.3123 mL
5 mM	0.4292 mL	2.1462 mL	4.2925 mL	21.4625 mL
10 mM	0.2146 mL	1.0731 mL	2.1462 mL	10.7312 mL
20 mM	0.1073 mL	0.5366 mL	1.0731 mL	5.3656 mL
50 mM	0.0429 mL	0.2146 mL	0.4292 mL	2.1462 mL
100 mM	0.0215 mL	0.1073 mL	0.2146 mL	1.0731 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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