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ZLN024

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Purity:99.82%

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COA HNMR LCMS

ZLN024

Catalog No. T13411Cas No. 723249-01-2

ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).

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Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$336	In Stock
10 mg	$497	In Stock
25 mg	$793	In Stock
50 mg	$1,130	In Stock
100 mg	$1,520	In Stock
500 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$341	In Stock

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Product Introduction

Bioactivity

Description	ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).
In vitro	ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312). ZLN024 increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 μM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 μM. ZLN024 also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 μM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 μM.
In vivo	C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased.

Chemical Properties

Molecular Weight	325.22
Formula	C13H13BrN2OS
Cas No.	723249-01-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/ml (153.74 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0748 mL	15.3742 mL	30.7484 mL	153.7421 mL
5 mM	0.6150 mL	3.0748 mL	6.1497 mL	30.7484 mL
10 mM	0.3075 mL	1.5374 mL	3.0748 mL	15.3742 mL
20 mM	0.1537 mL	0.7687 mL	1.5374 mL	7.6871 mL
50 mM	0.0615 mL	0.3075 mL	0.6150 mL	3.0748 mL
100 mM	0.0307 mL	0.1537 mL	0.3075 mL	1.5374 mL

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