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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $31 | In Stock | |
2 mg | $44 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $139 | In Stock | |
25 mg | $278 | In Stock | |
50 mg | $513 | In Stock | |
100 mg | $743 | In Stock | |
500 mg | $1,490 | In Stock | |
1 mL x 10 mM (in DMSO) | $79 | In Stock |
Description | (±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes. |
In vitro | Cannabinoid receptor 1 (CB1R) antagonists are considered promising for obesity treatment, but significant adverse effects have limited their use in clinical settings. Ibipinabant emerges as a potent [Ki (CB1)=7.8 nM] and selective [Ki (CB2)=7.943 nM] CB1 antagonist, exhibiting in vitro pharmacological properties akin to rimonabant, such as inverse agonism and the ability to penetrate the brain[3], with a notable affinity [pA2 for arachidonic acid release in CHO cells=9.9]. |
In vivo | Ibipinabant (3 mg/kg) significantly lowers unfasted glucose levels compared to rimonabant at equivalent doses on days 17, 28, and 38. Long-term ibipinabant administration notably slows diabetes progression in ZDF rats by moderating the rise in blood glucose and HbA1c levels over time. Additionally, ibipinabant decreases the evident hyperinsulinemia at 6-8 weeks of age and mitigates the sharp decline in insulin levels occurring 1-2 weeks thereafter[3]. |
Animal Research | Rats: SLV319, rimonabant and rosiglitazone are suspended in a 10% dimethylacetamide, 10% cremophor, 10% ethanol and 70% water vehicle. Drugs are administered by oral gavage in a volume of 2 mL/kg body weight at 09:00 hours every day. Treatment groups are as follows: (i) Vehicle: ad libitum access to food (vehicle), (ii) Vehicle: restricted access to food (20% less than average food intake of ad libitum vehicle-treated group for the first 3 days of the study, then 10% less than the average food intake of the ad libitum vehicle-treated group for the remainder of the study) (restricted), (iii) Rosiglitazone (4 mg/kg), (iv) Rimonabant (3 mg/kg) (RIM 3 mg/kg), (v) Rimonabant (10 mg/kg) (RIM 10 mg/kg), (vi) SLV319 (3 mg/kg) (IBI 3 mg/kg) and (vii) Ibipinabant (10 mg/kg) (IBI 10 mg/kg). Rosiglitazone is used as a positive control for its ability to delay β-cell decline, and rimonabant is used as a positive control for CB1 antagonism[3]. |
Alias | (±)-BMS6462, SLV319, (±)-SLV319 |
Molecular Weight | 487.4 |
Formula | C23H20Cl2N4O2S |
Cas No. | 362519-49-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (92.33 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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