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β,β-Dimethylacrylshikonin

Catalog No. T3S2344   CAS 24502-79-2
Synonyms: Dimethylacrylshikonin, β, β-Dimethylacrylshikonin

1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
β,β-Dimethylacrylshikonin Chemical Structure
β,β-Dimethylacrylshikonin, CAS 24502-79-2
Pack Size Availability Price/USD Quantity
20 mg In stock $ 130.00
1 mL * 10 mM (in DMSO) In stock $ 70.00
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Purity: 98.86%
Purity: 93.42%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
Source
Synonyms Dimethylacrylshikonin, β, β-Dimethylacrylshikonin
Molecular Weight 370.4
Formula C21H22O6
CAS No. 24502-79-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.7 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Kwak S , Jeong Y , Kim B , et al. β,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species[J]. Oncology Letters, 2014.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Obesity Compound Library Reprogramming Compound Library Anti-Colorectal Cancer Compound Library Anti-Tumor Natural Product Library Target-Focused Phenotypic Screening Library Anti-Prostate Cancer Compound Library Kinase Inhibitor Library Anti-Liver Cancer Compound Library Anti-Aging Compound Library

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Keywords

β,β-Dimethylacrylshikonin 24502-79-2 Chromatin/Epigenetic MAPK Metabolism HIF/HIF Prolyl-Hydroxylase ERK Isoarnebin I Inhibitor inhibit Dimethylacrylshikonin b, b-Dimethylacrylshikonin beta,beta-Dimethylacrylshikonin β,β Dimethylacrylshikonin b,b-Dimethylacrylshikonin β,βDimethylacrylshikonin beta, beta-Dimethylacrylshikonin β, β-Dimethylacrylshikonin inhibitor

 

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