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2',4'-DIHYDROXYCHALCONE

Catalog No. T8829 CAS 1776-30-3

Synonyms: 2',4'-DHC

2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects

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2',4'-DIHYDROXYCHALCONE Chemical Structure

2',4'-DIHYDROXYCHALCONE, CAS 1776-30-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 50.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 183.00
50 mg	In stock	$ 275.00
100 mg	In stock	$ 414.00
1 mL * 10 mM (in DMSO)	In stock	$ 77.00

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Purity: 99.59%

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Description

2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effects

In vitro

In the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked.?The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC.?The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced.?The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin.?Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90.?2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor[1].

Synonyms	2',4'-DHC
Molecular Weight	240.25
Formula	C15H12O3
CAS No.	1776-30-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (45.78 mM)

References and Literature

1. Seo Y H , Kim S S , Shin K S . In Vitro Antifungal Activity and Mode of Action of 2',4'-Dihydroxychalcone against Aspergillus fumigatus[J]. Mycobiology, 2015, 43(2):150-156. 2. Saba I , Nayab B , Subhra P , et al. Identification of 2′,4′-Dihydroxychalcone as an Antivirulence Agent Targeting HlyU, a Master Virulence Regulator in Vibrio vulnificus[J]. Molecules, 2018, 23(6):1492-.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Metabolism Compound Library Anti-Breast Cancer Compound Library Covalent Inhibitor Library Exosome Compound Library Anti-Cancer Compound Library Anti-Infection Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

Chetomin Eupalinolide A VER-49009 ML346 TRC051384 PF04929113 HSP90-IN-27 HA15

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Keywords

2',4'-DIHYDROXYCHALCONE 1776-30-3 Cytoskeletal Signaling Metabolism HSP 2',4'-DHC 2',4'DIHYDROXYCHALCONE 2',4' DIHYDROXYCHALCONE inhibitor inhibit

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