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2-Fluoroadenine

Catalog No. T20038 CAS 700-49-2

Synonyms: NSC-27364, NSC 27364, NSC27364

2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.

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2-Fluoroadenine, CAS 700-49-2

Pack Size	Availability	Price/USD
100 mg	In stock	$ 41.00
200 mg	In stock	$ 54.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.
In vitro	In Balb-3T3 cells, 2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses. In CEM cells, 2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. In nonproliferating MRC-5 cells, 2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity[2].

Synonyms	NSC-27364, NSC 27364, NSC27364
Molecular Weight	153.12
Formula	C5H4FN5
CAS No.	700-49-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.4 mg/mL (26.97 mM)

References and Literature

1. Rackwitz J, Kopyra J, Dąbkowska I, Ebel K, Ranković MLj, Milosavljević AR, Bald I. Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine. Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10248-52. doi: 10.1002/anie.201603464. Epub 2016 Aug 2. PubMed PMID: 27481662. 2. Collonnier C, Epert A, Mara K, Maclot F, Guyon-Debast A, Charlot F, White C, Schaefer DG, Nogué F. CRISPR-Cas9-mediated efficient directed mutagenesis and RAD51-dependent and RAD51-independent gene targeting in the moss Physcomitrella patens. Plant Biotechnol J. 2017 Jan;15(1):122-131. doi: 10.1111/pbi.12596. Epub 2016 Jul 22. PubMed PMID: 27368642; PubMed Central PMCID: PMC5253467. 3. Hassan AE, Abou-Elkhair RA, Parker WB, Allan PW, Secrist JA 3rd. 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases. Bioorg Chem. 2016 Apr;65:9-16. doi: 10.1016/j.bioorg.2015.12.006. Epub 2015 Dec 24. PubMed PMID: 26745284. 4. Hassan AEA, Abou-Elkhair RAI, Parker WB, Allan PW, Secrist JA 3rd. 6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase. Eur J Med Chem. 2016 Jan 27;108:616-622. doi: 10.1016/j.ejmech.2015.12.029. Epub 2015 Dec 17. PubMed PMID: 26724729.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Human Metabolite Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library DNA Damage & Repair Compound Library

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Keywords

2-Fluoroadenine 700-49-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis CEM Purine bases NSC-27364 Cytotoxicity MRC-5 Anticancer Inhibitor NSC 27364 NSC27364 2 Fluoroadenine inhibit 2Fluoroadenine inhibitor

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