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2-methoxycinnamaldehyde

Catalog No. T7452 CAS 1504-74-1

Synonyms: O-methoxycinnamaldehyde

2-Methoxycinnamaldehyde (2-MCA) is a natural compound of Cinnamomum cassia,has been widely studied with regard to its antitumor activity.

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2-methoxycinnamaldehyde, CAS 1504-74-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	2-Methoxycinnamaldehyde (2-MCA) is a natural compound of Cinnamomum cassia,has been widely studied with regard to its antitumor activity.
In vitro	2-methoxycinnamaldehyde(2-MCA) inhibited cell proliferation in SK-Hep-1 cells in a dose- and time-dependent manner. The inhibitory concentration (IC50) value following 48 hours of incubation was 25.72 μM[1].
Cell Research	Cells were seeded in 96-well culture plates (1×10^4 cells/well). After incubated for 24 hours, the cells were treated with different concentrations of 2-MCA for 24 hours, 48 hours, and 72 hours. The cell viability was determined by Cell Proliferation Kit II (XTT) following the manufacturer's protocol. The absorbance was measured using Tecan infinite M200 spectrophotometer at 492 nm with a reference wavelength of 650 nm[1].

Synonyms	O-methoxycinnamaldehyde
Molecular Weight	162.18
Formula	C10H10O2
CAS No.	1504-74-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 32mg/mL(197.3mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Perng D S , Tsai Y H , Cherng J , et al. Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde.[J]. Drug Design Development & Therapy, 2016, 10(7):141-153. 2. Young-Hee J , Soo-A K . 2-Methoxycinnamaldehyde inhibits the TNF-α-induced proliferation and migration of human aortic smooth muscle cells[J]. International Journal of Molecular Medicine, 2017, 39(1):191-198.

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Keywords

2-methoxycinnamaldehyde 1504-74-1 Apoptosis Others 2methoxycinnamaldehyde 2 methoxycinnamaldehyde 2-Methoxycinnamaldehyde inhibit Inhibitor O-methoxycinnamaldehyde inhibitor

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