Shopping Cart
- Remove All
Your shopping cart is currently empty
3,4-Dihydroxybenzylamine hydrobromide
🥰Excellent
Catalog No. T10104Cas No. 16290-26-9
Alias NSC 263475 hydrobromide
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
3,4-Dihydroxybenzylamine hydrobromide
🥰Excellent
Purity: 97.28%
Catalog No. T10104Alias NSC 263475 hydrobromideCas No. 16290-26-9
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $34 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "3,4-Dihydroxybenzylamine hydrobromide"
Thymidine
Cited
Thymidin, NSC 21548, DThyd, Deoxyribothymidine, 5-Methyldeoxyuridine
TWP291150-89-5
Thymidine (DThyd) is a cell synchronizing agent and a specific precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis and can cause cell cycle arrest in the G1/S phase.
- $45
Size
QTY
CitedGuanidine hydrochloride
Guanidinium chloride, Guanidine HCl, Aminoformamidine Hydrochloride, Aminoformamidine HCl
T041550-01-1
Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.
- $29
Size
QTY
5-Fluorouracil Cited
NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil
T098451-21-8
5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
- $30
Size
QTY
CitedProcaine
Vitamin H3, Spinocaine, Novocaine, Duracaine
T002959-46-1
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
- $30
Size
QTY
Folic acid Cited
Vitamin M, Vitamin B9, Pteroylglutamic acid, Folate, Folacin
T006259-30-3
Folic acid (Vitamin B9) is a vitamin B9 that is essential for the synthesis of DNA/RNA and for the production and maintenance of new cells. Folic acid deficiency can lead to anemia, neural tube closure defects, tumors, aging, and other diseases.
- $45
Size
QTY
CitedN-Nitrosodiethylamine
NDEA, Diethylnitrosamine
T3545555-18-5
N-Nitrosodiethylamine (NDEA) is a potent hepatocarcinogenic dialkylnitrosoamine primarily found in water, tobacco smoke, cheddar cheese, cured and fried meals, and many alcoholic beverages. NDEA is responsible for changes in nuclear enzymes related to DNA repair/replication and induces various tumors in all animal species, targeting mainly the liver, nasal cavity, trachea, lung, and esophagus.
- $41
Size
QTY
Ribavirin Cited
Tribavirin, RTCA, NSC-163039, ICN-1229
T068436791-04-5
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
- $39
Size
QTY
CitedTemozolomide
Cited
TZM, TMZ, NSC 362856, CCRG 81045
T117885622-93-1
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.
- $42
Size
QTY
CitedAcyclovir Cited
Acycloguanosine, Aciclovir
T145459277-89-3
Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family.
- $39
Size
QTY
CitedTrimethoprim
NSC-106568, NIH 204, BW 56-72
T1153738-70-5
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
- $45
Size
QTY
Resveratrol Cited
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
- $36
Size
QTY
CitedPemetrexed
Pemetrexed acid, LY231514 Disodium Hydrate, LY231514
T0189137281-23-3
Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
- $33
Size
QTY
Select Batch
Purity:97.28%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity. |
| In vitro | 3,4-Dihydroxybenzylamine hydrobromide (1 μM-10 mM; 48 hours) inhibits the growth of melanoma cell lines with IC50 values of 30, 84, 90, and 68 μM for SK-MEL-30, SK-MEL-2, SK-MEL-3, and RPMI-7951 cells, respectively, and exhibits IC50 values of 10, 25, 67, and 184 μM for S91A, S91B, L1210, and SCC-25 cells. Cytotoxicity in SK-MEL-2 and SK-MEL-28 is enhanced by buthionine sulfoximine (BSO), decreasing the IC50 values of 3,4-DHBA by 127% in SK-MEL-28 and by 148% in SK-MEL-2 cells[1]. |
| In vivo | 3,4-Dihydroxybenzylamine hydrobromide (200, 400, 600 and 800 mg/kg; i.p.; 21 days) has different effects at different doses, the median life-span are 17, 24.5, 26, 29 and 25 days respectively. 3,4-Dihydroxybenzylamine hydrobromide (1000 mg/kg; i.p.; 7 days) has the least toxic effect in non-tumor-bearing B6D2F1 mice,and mice is tolerated at this dose[2]. |
| Cell Research | Cell Line: Human and Murine Melanoma Cell Lines; Non-Melanoma Cell Lines
Concentration: 1 μM-10 mM Incubation Time: 48 hours [1] |
| Animal Research | Animal Model: C57BL/6 mice with B6D2F1 cells
Dosage: 200 mg/kg, 400 mg/kg, 600 mg/kg, and 800 mg/kg Administration: Intraperitoneal injection [2] |
| Alias | NSC 263475 hydrobromide |
| Molecular Weight | 220.06 |
| Formula | C7H10BrNO2 |
| Cas No. | 16290-26-9 |
| Smiles | Br.NCc1ccc(O)c(O)c1 |
| Relative Density. | 1.309g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (363.54 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
tyrosinaseTumorRNASynthesisRNA SynthesisNSC-263475 HydrobromideNSC263475 HydrobromideNSC-263475NSC263475NSC 263475 HydrobromideNSC 263475melanomaInhibitorinhibitDNASynthesisDNA/RNA SynthesisDNA SynthesisDNA polymerase3,4-Dihydroxybenzylamine Hydrobromide3,4Dihydroxybenzylamine hydrobromide3,4-Dihydroxybenzylamine3,4 Dihydroxybenzylamine hydrobromide
Preview
Related Tags: buy 3,4-Dihydroxybenzylamine hydrobromide | purchase 3,4-Dihydroxybenzylamine hydrobromide | 3,4-Dihydroxybenzylamine hydrobromide cost | order 3,4-Dihydroxybenzylamine hydrobromide | 3,4-Dihydroxybenzylamine hydrobromide chemical structure | 3,4-Dihydroxybenzylamine hydrobromide in vivo | 3,4-Dihydroxybenzylamine hydrobromide in vitro | 3,4-Dihydroxybenzylamine hydrobromide formula | 3,4-Dihydroxybenzylamine hydrobromide molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.