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3-Hydroxy agomelatine

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3-Hydroxy agomelatine

Catalog No. T10114Cas No. 166526-99-4

3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).

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Pack Size	Price	Availability
1 mg	$58	5 days
5 mg	$168	5 days
10 mg	$232	7-10 days
25 mg	$389	7-10 days
50 mg	$572	7-10 days

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Product Introduction

Bioactivity

Description	3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
Targets&IC50	5-HT2C receptor:1.8 μM (ki), 5-HT2C receptor:3.2 μM
In vitro	The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (Ki = 1.8 μM). Agomelatine, S 21517, and 3-Hydroxy agomelatine (0.1-100 μM) are antagonists at 5-HT2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine.
In vivo	Increasing doses (1.25~40 mg/kg, i.p.) of 3-Hydroxy agomelatine does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat.

Chemical Properties

Molecular Weight	259.3
Formula	C15H17NO3
Cas No.	166526-99-4

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