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3-Hydroxy agomelatine
Catalog No. T10114Cas No. 166526-99-4
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
3-Hydroxy agomelatine
Catalog No. T10114Cas No. 166526-99-4
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $173 | In Stock | |
| 5 mg | $398 | 7-10 days | |
| 10 mg | $576 | 7-10 days | |
| 25 mg | $945 | 7-10 days | |
| 50 mg | $1,520 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM). |
| Targets&IC50 | 5-HT2C receptor:1.8 μM (ki), 5-HT2C receptor:3.2 μM |
| In vitro | The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (Ki = 1.8 μM). Agomelatine, S 21517, and 3-Hydroxy agomelatine (0.1-100 μM) are antagonists at 5-HT2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine. |
| In vivo | Increasing doses (1.25~40 mg/kg, i.p.) of 3-Hydroxy agomelatine does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat. |
| Molecular Weight | 259.3 |
| Formula | C15H17NO3 |
| Cas No. | 166526-99-4 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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