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3-O-Acetyloleanolic acid
🥰Excellent
Catalog No. T2S1396Cas No. 4339-72-4
3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations.
3-O-Acetyloleanolic acid
🥰Excellent
Purity: 99.20%
Catalog No. T2S1396Cas No. 4339-72-4
3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $123 | In Stock | |
| 10 mg | $172 | In Stock | |
| 25 mg | $288 | In Stock | |
| 50 mg | $432 | In Stock | |
| 100 mg | $626 | In Stock | |
| 500 mg | $1,290 | In Stock |
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Purity:99.20%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations. |
| In vitro | Expression of TRAIL-mediated apoptosis signaling-related death receptor DR5 was increased in 3-O-acetyloleanolic acid-treated HCT-116 cells. Activation of caspase-8 and caspase-3, critical mediators of extrinsic apoptosis signaling, was also increased by 3-O-acetyloleanolic acid. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5. |
| Cell Research | Modulation of phosphatidylserine externalization during apoptosis was measured using annexin V conjugated with the fluorescent dye fluorescein isothiocyanate (FITC). The HCT-116 cells were seeded onto 6-well plates at a density of 3*10^5 cells/well. After treatment with 25 uM 3-O-acetyloleanolic acid for 6 h, the cells were stained with the annexin V-FITC conjugate, and then imaged at a^40 objective magnification using a confocal laser scanning microscope. |
| Molecular Weight | 498.74 |
| Formula | C32H50O4 |
| Cas No. | 4339-72-4 |
| Smiles | [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](OC(C)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O |
| Relative Density. | 1.10 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2.5 mg/mL (5.01 mM)  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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