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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $29 | In Stock | |
2 mg | $43 | In Stock | |
5 mg | $74 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $173 | In Stock | |
50 mg | $259 | In Stock | |
100 mg | $376 | In Stock | |
200 mg | $523 | In Stock |
Description | 3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations. |
In vitro | Expression of TRAIL-mediated apoptosis signaling-related death receptor DR5 was increased in 3-O-acetyloleanolic acid-treated HCT-116 cells. Activation of caspase-8 and caspase-3, critical mediators of extrinsic apoptosis signaling, was also increased by 3-O-acetyloleanolic acid. 3-O-acetyloleanolic acid induces apoptosis in HCT-116 cells mediated by an extrinsic apoptosis signaling cascade via up-regulation of DR5. |
Cell Research | Modulation of phosphatidylserine externalization during apoptosis was measured using annexin V conjugated with the fluorescent dye fluorescein isothiocyanate (FITC). The HCT-116 cells were seeded onto 6-well plates at a density of 3*10^5 cells/well. After treatment with 25 uM 3-O-acetyloleanolic acid for 6 h, the cells were stained with the annexin V-FITC conjugate, and then imaged at a^40 objective magnification using a confocal laser scanning microscope. |
Molecular Weight | 498.74 |
Formula | C32H50O4 |
Cas No. | 4339-72-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
Solubility Information | DMSO: 2.5 mg/mL (5.01 mM) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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