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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $97 | In Stock | |
5 mg | $327 | In Stock | |
10 mg | $497 | In Stock | |
25 mg | $793 | In Stock | |
50 mg | $1,130 | In Stock | |
100 mg | $1,520 | In Stock | |
1 mL x 10 mM (in DMSO) | $328 | In Stock |
Description | 4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM). |
In vitro | 4E2RCat disrupts the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), thereby inhibiting cap-dependent translation. This action significantly reduces replication of human coronavirus 229E (HCoV-229E), decreasing both the proportion of infected cells and the levels of infectious virus both inside and outside cells. The inhibition of cap-dependent translation by 4E2RCat occurs in a dose-dependent manner, specifically targeting cap-dependent FF translation without affecting EMCV IRES-driven Ren translation. Additionally, 4E2RCat curtails coronavirus replication reliant on dose and duration[1]. |
In vivo | 4E2RCat impedes protein synthesis in vivo, and this effect is not due to elevated cell death[1]. |
Molecular Weight | 455.93 |
Formula | C22H14ClNO4S2 |
Cas No. | 432499-63-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 15.5 mg/mL (34.00 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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