Shopping Cart
- Remove All
Your shopping cart is currently empty
4E2RCat
Catalog No. T14044Cas No. 432499-63-3
4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and effectively blocks coronavirus replication, as evidenced by reduced viral protein expression and decreased production of infectious virus.
4E2RCat
Catalog No. T14044Cas No. 432499-63-3
4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and effectively blocks coronavirus replication, as evidenced by reduced viral protein expression and decreased production of infectious virus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $196 | In Stock | |
| 10 mg | $298 | In Stock | |
| 25 mg | $476 | In Stock | |
| 50 mg | $678 | In Stock | |
| 100 mg | $912 | In Stock | |
| 200 mg | $1,220 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "4E2RCat"
Azoramide
T4304932986-18-0
Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.
- $31
Size
QTY
4EGI-1
Cited
4EGI 1
T2665315706-13-9
4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).
- $37
Size
QTY
Cited
DNL-343, DNL 343
T788762278265-85-1In house
DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS).
- $148
Size
QTY
MSU-42011
T774992456434-36-7In house
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist. It potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level. MSU-42011 has demonstrated antitumor activity in a [kras]-driven mouse model of lung cancer and is effective for the treatment of preclinical [kras]-driven lung cancer with immunomodulatory activity.
- $41
Size
QTY
GP 1a
T41231511532-96-0In house
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and increases P-ERK1/2 expression in HL-60 cells in vitro. GP 1a is beneficial for skin wound healing. GP 1a inhibits inflammation and fibrogenesis while promoting epithelial re-formation.
- $51
Size
QTY
ATPγS tetralithium salt
ATP-gamma-S tetralithium salt
T2259293839-89-5In house
ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.
- $148
Size
QTY
BTdCPU Cited
T71501257423-87-2
BTdCPU is a potent activator of heme-regulated eIF2α kinase (HRI) . BTdCPU promotes eIF2α phosphorylation and induced apoptosis in resistant cell.
- $148
Size
QTY
CitedISRIB (trans-isomer)
trans-ISRIB, trans-isomer, ISRIB trans-isomer, ISRIB
T61831597403-47-8
ISRIB (trans-isomer) is a potent inhibitor of PERK (IC50=5 nM) that restores protein translation and prevents SG formation in the presence of P-eIF2α.
- $31
Size
QTY
GCN2-IN-6
T113742183470-09-7In house
GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9
- $117
Size
QTY
Salubrinal Cited
T3045405060-95-9
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
- $35
Size
QTY
CitedSelect Batch
Purity:96.48%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and effectively blocks coronavirus replication, as evidenced by reduced viral protein expression and decreased production of infectious virus. |
| Targets&IC50 | eIF4E-eIF4G:13.5 μM |
| In vitro | 4E2RCat disrupts the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), thereby inhibiting cap-dependent translation. This action significantly reduces replication of human coronavirus 229E (HCoV-229E), decreasing both the proportion of infected cells and the levels of infectious virus both inside and outside cells. The inhibition of cap-dependent translation by 4E2RCat occurs in a dose-dependent manner, specifically targeting cap-dependent FF translation without affecting EMCV IRES-driven Ren translation. Additionally, 4E2RCat curtails coronavirus replication reliant on dose and duration[1]. |
| In vivo | 4E2RCat impedes protein synthesis in vivo, and this effect is not due to elevated cell death[1]. |
| Molecular Weight | 455.93 |
| Formula | C22H14ClNO4S2 |
| Cas No. | 432499-63-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15.5 mg/mL (34.00 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy 4E2RCat | purchase 4E2RCat | 4E2RCat cost | order 4E2RCat | 4E2RCat chemical structure | 4E2RCat in vivo | 4E2RCat in vitro | 4E2RCat formula | 4E2RCat molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.