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5-HT1AR agonist 2
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Catalog No. T201624
5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.
5-HT1AR agonist 2
5-HT1AR agonist 2
😃Good
Catalog No. T201624
5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice.
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Product Introduction
Bioactivity
Chemical Properties
| Description | 5-HT1AR Agonist 2 (Compound 4f) is a potent agonist of the 5-HT1A receptor with a Ki value of 10.0 nM. It also binds to SERT, D2, and 5-HT6 receptors with Ki values of 2.8 nM, 23 nM, and 192 nM, respectively. Furthermore, this compound demonstrates stability in microsomes and induces hypothermia in mice. |
| Targets&IC50 | 5-HT6 Receptor:192nM(Ki), 5-HT1A Receptor:10nM(Ki), D2 Receptor:23nM(Ki) |
| In vitro | 5-HT 1A R agonist 2 exhibits high stability in human microsomes with an intrinsic clearance rate of less than 115.5 μL/min/mg and a half-life (t1/2) exceeding 209 minutes at a concentration of 10 μM. |
| In vivo | The compound, 5-HT 1A R agonist 2, administered at doses ranging from 5-20 mg/kg intraperitoneally (i.p.), induces hypothermia in male CD-1 mice 30 minutes prior to testing, similarly to the effect observed with 8-OH-DPAT. |
| Molecular Weight | 521.61 |
| Formula | C31H31N5O3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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