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6-Thio-2'-Deoxyguanosine

🥰Excellent
Catalog No. T6746Cas No. 789-61-7
Alias β-TGdR, 6-Thio-dG

6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.

6-Thio-2'-Deoxyguanosine

6-Thio-2'-Deoxyguanosine

🥰Excellent
Purity: 97.52%
Catalog No. T6746Alias β-TGdR, 6-Thio-dGCas No. 789-61-7
6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.
Pack SizePriceAvailabilityQuantity
5 mg$50In Stock
10 mg$72In Stock
25 mg$146In Stock
50 mg$263In Stock
100 mg$447In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:97.52%
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Product Introduction

Bioactivity
Description
6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.
In vitro
6-Thio-dG induces telomere dysfunction and results in progressive telomere shortening in telomerase-positive human cancer cells and hTERT-expressing human fibroblasts. In tested cancer cells, 6-thio-dG inhibits cell viability with IC50 values between 0.7 and 2.9 μM. [1]
In vivo
In mice bearing A549 lung cancer xenografts, 6-Thio-dG (2 mg/kg, i.p.) decreases the tumorigenicity of A549 Cells by inducing telomere dysfunction. [1]
Cell Research
Cells are plated in growth media in 96-well plates. Cells are incubated for 1 week and treated with varying concentrations of 6-thio-dG and 6-thioguanine or DMSO every 3 days. The 96-well plates are analyzed according the manufacturer's directions for the CellTiterGlo luminescent cell viability assay to obtain IC50 values. The IC50 is defined as the concentration of drug at which 50% of the cells are inhibited by the drug. Sigmoidal dose–response curves are used to calculate IC50 values. All samples are analyzed in triplicate, and SDs are from two independent experiments.(Only for Reference)
Aliasβ-TGdR, 6-Thio-dG
Chemical Properties
Molecular Weight283.31
FormulaC10H13N5O3S
Cas No.789-61-7
SmilesNc1nc(=S)c2ncn([C@H]3C[C@H](O)[C@@H](CO)O3)c2[nH]1
Relative Density.2.02g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 52 mg/mL (183.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5297 mL17.6485 mL35.2970 mL176.4851 mL
5 mM0.7059 mL3.5297 mL7.0594 mL35.2970 mL
10 mM0.3530 mL1.7649 mL3.5297 mL17.6485 mL
20 mM0.1765 mL0.8824 mL1.7649 mL8.8243 mL
50 mM0.0706 mL0.3530 mL0.7059 mL3.5297 mL
100 mM0.0353 mL0.1765 mL0.3530 mL1.7649 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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