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H2-Gamendazole

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Catalog No. T72076Cas No. 877768-84-8

H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator.

H2-Gamendazole

H2-Gamendazole

🥰Excellent
Purity: 97.36%
Catalog No. T72076Cas No. 877768-84-8
H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator.
Pack SizePriceAvailabilityQuantity
1 mg$119In Stock
5 mg$333In Stock
10 mg$498In Stock
25 mg$885In Stock
50 mg$1,190In Stock
100 mg$1,630In Stock
1 mL x 10 mM (in DMSO)$376In Stock
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Purity:97.36%
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Product Introduction

Bioactivity
Description
H2-Gamendazole is a novel compound for spermatogenesis inhibition and cancer therapy as an inhibitor of heat shock proteins and/or elongation factor 1 alpha, and is an Hsp90 regulator.
Targets&IC50
MCF-7 cells:∼100 μM, ADPKD cells:5–10 μM, ErbB2:50 μM
In vitro
H2-Gamendazole (H2-GMZ ; 0-100 μM) was effective in rapidly blocking forskolin-induced, Cl-mediated short-circuit currents in human ADPKD cells, and it significantly inhibited both cAMP- and epidermal growth factor-induced proliferation of ADPKD cells.[1]
H2-GMZ (50 μM)-treated ADPKD cells showed decreased phosphorylated ERK and decreased hyperphosphorylated retinoblastoma levels through western blot analysis.[1]
H2-GMZ (50 μM ; 24、48、72 h) treatment also decreased ErbB2, Akt, and cyclin-dependent kinase 4 and it decreased levels of the cystic fibrosis transmembrane conductance regulator Cl channel protein.[1]
In vivo
H2-Gamendazole (20 mg/kg ; intraperitoneal injections) was effective in slowing postnatal cyst formation and kidney enlargement in the ---Pkd1flox/flox: Pkhd1-Cre mouse model.[1]
Chemical Properties
Molecular Weight417.21
FormulaC18H13Cl2F3N2O2
Cas No.877768-84-8
SmilesC(N1C=2C(C(CCC(O)=O)=N1)=CC=C(C(F)(F)F)C2)C3=C(Cl)C=C(Cl)C=C3
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (71.91 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3969 mL11.9844 mL23.9687 mL119.8437 mL
5 mM0.4794 mL2.3969 mL4.7937 mL23.9687 mL
10 mM0.2397 mL1.1984 mL2.3969 mL11.9844 mL
20 mM0.1198 mL0.5992 mL1.1984 mL5.9922 mL
50 mM0.0479 mL0.2397 mL0.4794 mL2.3969 mL

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